Osteons are cylindrical structures of bone created by matrix resorbing osteoclasts, followed by osteoblasts that deposit new bone. Osteons align with the principal loading direction and it is thought that the osteoclasts are directed by osteocytes, the mechanosensitive cells that reside inside the bone matrix. These osteocytes are presumably controlled by interstitial fluid flow, induced by the physiological loading of bones. Here I consider the stimulation of osteocytes while the osteon is closed by osteoblasts. In a conceptual finite element model, (...) bone is considered a poro‐elastic material and subjected to locomotion‐induced loading conditions. It appears that the magnitude of flow is constant along the closing cone, while shear strain rate in the bone matrix diminishes linearly with the deposition of bone. This suggests that shear strain rate, rather than fluid flow, is the physical cue that controls osteocytes and bone deposition in newly formed osteons. (shrink)

As Anthony Tol explains in his general introduction to (his translation of) Vollenhoven's 1926 inaugural address, the Reformed epistemology that Vollenhoven espouses here is essentially three-layered. Most basic is the intuition - the starting point of all knowing. It starts with discerning. Then there is knowledge. At this point language, communication, and judgments are relevant. The third layer is thought. Thought may disclose and renew or criticize and correct against the background of what we know. Thought is also central to (...) concept formation. The factor that runs through these three layers is truth, taken realistically. It has its seat in the intuition of discerning. It is central to knowledge, for the essence of knowledge is said to be "possessing truth." And in connection with thought, or more particularly in concept formation, the latter is described as "truth grasped in a form." Apart from advocating his own understanding of epistemology in this inaugural address, Vollenhoven takes issue with how epistemology is generally understood. The critique is cast in a historical overview. (shrink)

We examined if cancer patients' health-related quality of life (HRQoL) scores on the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 are affected by the specific time point, before or during treatment, at which the questionnaire is completed, and whether this could bias the overall treatment comparison analyses. A 'completion-time window' variable was created on three closed EORTC randomised control trials in lung (non-small cell lung cancer, NSCLC) and colorectal cancer (CRC) to indicate when the QLQ-30 was completed (...) relative to chemotherapy cycle dates, defined as 'before', 'on' and 'after'. HRQoL mean scores were calculated using a linear mixed model. Statistically significant differences (P < 0.05) were observed on 6 and 5 scales for 'on' and 'after' comparisons in the NSCLC and two-group CRC trial, respectively. As for the three-group CRC trial, several statistical differences were observed in the 'before' to 'on' and the 'on' to 'after' comparisons. For all three trials, including the 'completion-time window' variable in the model resulted in a better fit, but no substantial changes in the treatment effects were noted. We showed that considering the exact timing of completion within specified windows resulted in statistical and potentially clinically significant differences, but it did not alter the conclusions of treatment comparison in these studies. (shrink)

AimThe neurocognitive basis of Developmental Coordination Disorder remains an issue of continued debate. This combined systematic review and meta-analysis provides a synthesis of recent experimental studies on the motor control, cognitive, and neural underpinnings of DCD.MethodsThe review included all published work conducted since September 2016 and up to April 2021. One-hundred papers with a DCD-Control comparison were included, with 1,374 effect sizes entered into a multi-level meta-analysis.ResultsThe most profound deficits were shown in: voluntary gaze control during movement; cognitive-motor integration; practice-/context-dependent (...) motor learning; internal modeling; more variable movement kinematics/kinetics; larger safety margins when locomoting, and atypical neural structure and function across sensori-motor and prefrontal regions.InterpretationTaken together, these results on DCD suggest fundamental deficits in visual-motor mapping and cognitive-motor integration, and abnormal maturation of motor networks, but also areas of pragmatic compensation for motor control deficits. Implications for current theory, future research, and evidence-based practice are discussed.Systematic Review RegistrationPROSPERO, identifier: CRD42020185444. (shrink)

An outline of the life of Heraclides and his fragmentary writings (on the theory of matter, astronomy, ethical and religious topics) is followed by an attempt to reconstruct his thought. He emerges as not so much a profound thinker as a many-sided writer of considerable literary gifts and occasional flashes of brilliance.

The following analysis has been undertaken mainly for the purpose of presenting a sample of a method which, as the writer holds, would, if widely and consistently applied, tend considerably to reduce the number and the significance of epistemological problems. The presuppositions characteristic of this method might be summarized in these five statements: 1)You cannot make discoveries by changing the meaning of terms.2)There is wisdom in common sense since it represents the accumulated experience of the race.3)It cannot be impossible to (...) work out common sense into a consistent terminology.4)It is when we lack the patience to do this that epistemological problems seem to arise.5)But when such a terminology is worked out, it will prove rather disappointing since it will just express, in a somewhat clarified form, what all the world has always been aware of. (shrink)

The connection between William of Ockham's philosophy and his politics has long been a subject of debate among scholars. Many have seen his nominalist epistemology, which asserts that the individual thing is the object of knowledge, as contributing towards his focus on the individual in his political thought. In her most recent article, ‘Ockham’s Right Reason and the Genesis of the Political as „Absolutist”’, Janet Coleman supports this argument concerning the influence of Ockham's philosophical individualism upon his political individualism. But (...) she also provides a different and, I believe, more important argument as to how Ockham's philosophical epistemology is connected to his politics: that what man can know about himself and others through right reason is Ockham's starting point for analysing human authority. This article attempts to support Coleman's argument that the role of right reason in the life of the individual has significant consequences for Ockham's notion of political rule. This is done through a detailed analysis of the specific role of right reason in Ockham's theory of the virtuous act, and how this treatment of right reason can be said to influence Ockham's notion of the purpose and methodology of political rule. Specifically, Ockham's notion of right reason in his ethical theory plays out in his political theory by defining the limitations of political knowledge, and thereby creating a pronounced discontinuity between the function of the individual as a self-ruler and the function of the political ruler. (shrink)

SummaryThe ethical fundaments of research are objectivity and logic. The subjective and objective elements in the procedure: formulation of a problem — hypothesis — experimentation — selection of arguments — theory are discussed with examples from experimental biology, foremost plant physiology. A certain amount of subjectivity is essential in research, but violations of ethical rules beyond that are not uncommon. The importance of a paradigm is emphasized; research ethics may be low under pre‐paradigm conditions. The reasons for lacking ethics are (...) discussed, and the difficulty for publishing media to control research ethics is emphasized. (shrink)

Robert Darnton has recently found that L.S. Mercier's utopia, L'An 2440, was the most widely sold clandestine work of the late eighteenth century. This article first attempts to explain the appeal of the book to contemporaries. It then notes the sudden and complete eclipse of the work and offers an explanation for this based on the political achievements of the French Revolution on the one hand and on a shift in the climate of opinion on the other.

In this article I deal with difficulties, textual and exegetical, in ten passages of the Agamemnon. In some passages there is wide agreement on the sense required, but not on the remedies proposed for a corrupt reading: here I venture to put forward fresh proposals that seem to possess a reasonable1 degree of palaeo-graphical probability . In another passage I argue for a new interpretation with its appropriate emendation . In some cases where the sense is hardly in doubt and (...) the text not certainly corrupt, I propose what seems on linguistic or other grounds a preferable reading , or I argue in favour of some other scholar's proposal . Finally, where there can be little, if any, likelihood of successful restoration, I offer a tentative suggestion which may give at least an approximation to the original text. (shrink)